Helping you advance your drug discovery efforts
Biologics and More
  • © 2024 Jim McGuire Contact Me 0

Biologics and More

Pharmacology Consulting Services

Molecular Pharmacology

Specializing in G Protein-Coupled Receptors (GPCRs) and Receptor Tyrosine Kinases (RTKs), we provide expert guidance in understanding receptor behavior and interactions to inform drug development strategies.

Structure-Activity Relationship (SAR)
Analyze and optimize the relationship between chemical structure and biological activity, aiding in the design of more effective and selective compounds.

Cell-based and Biochemical Assays
Develop and implement robust cell-based and biochemical assays to evaluate compound efficacy, potency, and mechanism of action, ensuring accurate and reliable data.

Target Confirmation

Confirm and validate biological targets to ensure your drug candidates are interacting with the intended targets, increasing the likelihood of therapeutic success.

Disease Mechanism Elucidation
Investigate and elucidate disease mechanisms at the molecular level to inform target selection and drug development strategies, enhancing the relevance and impact of your therapeutic approach.

Species Translation

Conduct studies to ensure effective translation of pharmacological data across species, facilitating the progression from preclinical to clinical stages with greater confidence.

Varied Molecular Scaffolds
Expertise in diverse molecular scaffolds including peptides, proteins, fusion proteins, antibodies, multi-agonists, and small molecules, enabling the development of innovative and versatile therapeutic agents.

PK/PD Assays for Preclinical Studies
Design and execute pharmacokinetic (PK) and pharmacodynamic (PD) assays to support preclinical studies, providing critical data on drug absorption, distribution, metabolism, and excretion (ADME) properties.